Comparison

Evidence you can trust, with citations you can verify

OpenEvidence made AI clinical search mainstream. Primary AI is built for physicians who want answers grounded in publicly accessible medical content, with location-aware guidance and direct links to cited public pages.

For clinical decision support only. Always verify with primary sources. Not a substitute for professional judgment.

How Primary AI compares

Both tools surface evidence-based answers at the point of care. The difference is where the evidence comes from — and whether you can trace and trust every citation.

Primary AI
Founded by a practicing physician
OpenEvidence
Founded by a data scientist (PhD)
Primary AI
Every citation verified, never fabricated
OpenEvidence
Cites sources; independent reviews note hallucination & transparency concerns
Primary AI
Location-aware guidelines (US + Canadian national & society bodies)
OpenEvidence
US-focused, NPI-gated
Primary AI
Local antibiotic resistance patterns (state/province antibiograms)
OpenEvidence
Not surfaced
Primary AI
Direct links to cited public pages
OpenEvidence
Citation links provided
Primary AI
Grounded in landmark trials & current guidelines
OpenEvidence
Partial
Primary AI
Widely adopted across US clinicians
OpenEvidence
~65% of US physicians
Yes Partial No

Transparent by design

Primary AI searches publicly accessible medical content and public guidance. Each answer links to the cited public page when one is available.

The honest verdict

OpenEvidence earned its place through broad adoption among US physicians. If you practice in the US and want a widely used AI search tool, it is a strong option.

Primary AI is for physicians who want to check the evidence behind every answer through direct citation links and location-aware guidance.

Ask your first clinical question

See the difference that verified, transparent citations make at the point of care.

Start asking

For clinical decision support only. Always verify with primary sources. Not a substitute for professional judgment.